Data/hora: 20/05/2024 06:46:43

Provedor de dados: | Brazilian Journal of Microbiology
País: | Brazil
Título: | In vitro synergistic activity of antibiotic combinations against Brucella melitensis using E-test methodology
Autores: | Kilic,Selcuk; Dizbay,Murat; Hizel,Kenan; Arman,Dilek.
Data: | 2008-06-01
Ano: | 2008
Palavras-chave: | Brucella melitensis; Antibiotics; Synergism.
Resumo: | The treatment of brucellosis is still problematic, because of high rates of treatment failure or relapses. As the microorganism is an intracellular pathogen, treatment requires combined regimens. However, limited existing data on in vitro combinations are avaliable for Brucellae. The aim of this study was to investigate the in vitro efficacy of various traditional and new antibiotic combinations against 16 Brucella melitensis strains. The combination effect of antimicrobial agents was evaluated by E-test synergy method to obtain a fractional inhibitory concentration (FIC) index. Co-Trimoxazole (SXT) and moxifloxocin (MXF) exhibited the lowest MIC, while Rifampin (RIF) had the highest MIC in the study. Combinations with RIF showed the best synergistic activity (100% of RIF-tetracycline (TET), and 87.5% of RIF-SXT). Synergistic activity was also detected at seven (43.7%) of ciprofloxocin (CIP)-SXT, four (25%) of TET-MXF, and two (12.5%) of TET-SXT combinations. The combinations that demonstrated additivity were TET-SXT, CIP-SXT and TET-MXF. Antagonism was observed only with the TET-Streptomycin (STR) combination in three strains (18.8%). Further work including randomized controlled clinical trials is required to fully evaluate the usefulness of these data.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200006
Editor: | Sociedade Brasileira de Microbiologia
Relação: | 10.1590/S1517-83822008000200006
Formato: | text/html
Fonte: | Brazilian Journal of Microbiology  v.39 n.2 2008
Fonte: | info:eu-repo/semantics/openAccess